Soul Care (2016)

Dr. Rhodes begins a fellowship in cardiothoracic surgery, only to have problems with his new boss. Dr. Choi is the new chief resident. Dr. Charles approaches Sarah with an interesting opportunity that catches her off-guard. April faces her recently discovered illness.

Directed By: Arthur W. Forney
Writer: Diane Frolov

Win Loss (2016)

Dr. Manning and Dr. Rhodes separately treat complicated cases involving sick babies, only to uncover that the two cases could actually be intertwined. Elsewhere, Dr. Halstead and Dr. Charles treat a homeless man with an upbeat disposition who sheds some valuable insight that prompts one of the doctors to learn a thing or two along the way. Dr. Choi has a Navy corpsman follow him for the day as they deal with the toll of gang violence in the city, while Dr. Reese tries to understand the delicate balance required in her new position.

Directed By: David Rodriguez
Writer: Eli Talbert

Directed By: Michael Waxman
Writer: Stephen Hootstein

Brother's Keeper (2016)

Several patients are discovered to have the same rare infection, prompting Dr. Charles' daughter Robyn, an epidemiologist, to be brought in to find the common link. Dr. Choi and Dr. Rhodes work on an elderly man who is discovered to be very ill, but a conflict in how to best treat him develops between his son and his young girlfriend. Meanwhile, Dr. Reese tries to help a young drug addict and Maggie tends to a patient who is dear to her heart.

Directed By: Stephen Cragg
Writer: Jeff Drayer

Extreme Measures (2016)

A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead, April and her fourth-year medical resident brother Noah, who must perform a difficult procedure in the field. A mother brings in her 8-year-old girl experiencing a sudden hearing loss and Dr. Manning is left to tend to the case, which takes a complicated turn. Dr. Choi deals with Olga, a woman who is malnourished, prompting him to bring in Dr. Charles to help assess the case. Meanwhile, Goodwin takes measures to get her personal life in order.